EU new version of the Notice to Applicants incorporating the revised version of the CTD (September 2002):

http://ec.europa.eu/enterprise/pharmaceuticals/eudralex/vol2_en.htm 

M4eCTD and eCTD Q&As are published on the EMEA eSubmission website

Questions & Answers

http://www.emea.europa.eu/pdfs/human/ich/288799en.pdf 

CTD available on MHLW's web site :  

http://www.pmda.go.jp/ich/m4.htm (Japanese)

CTD available on FDA's web site :

Organization of the CTD : 
http://www.fda.gov/cder/guidance/4539O.htm
or pdf document http://www.fda.gov/cder/guidance/4539O.PDF

The CTD Quality :
http://www.fda.gov/cder/guidance/4539Q.htm

The pdf document : http://www.fda.gov/cder/guidance/4539Q.PDF

The CTD Safety :
http://www.fda.gov/cder/guidance/4539S.htm

The pdf document : http://www.fda.gov/cder/guidance/4539S.PDF

The CTD Safety Appendices :
http://www.fda.gov/cder/guidance/4539sap.htm
The pdf document : http://www.fda.gov/cder/guidance/4539sap.pdf

The CTD Efficacy :
http://www.fda.gov/cder/guidance/4539E.htm

The pdf document : http://www.fda.gov/cder/guidance/4539E.pdf

The eCTD :
The pdf document : http://www.fda.gov/cder/guidance/5415fnl.pdf

Note that the revised version of CTD (September 2002) should be republished in synchrony with the revised final "FDA general consideration guidance document"